Journal Articles Respiratory Physiology & Neurobiology Year : 2020

Hemostasis in highlanders with excessive erythrocytosis at 5100 m: Preliminary data from the highest city of the world

Abstract

Little is known about hemostasis modifications induced by chronic hypoxic exposure in high-altitude residents, especially in those who develop excessive erythrocytosis (EE, i.e. hemoglobin concentration ≥ 21 g·dL-1 in male and ≥ 19 g·dL-1 in female). The aim of this preliminary study was to assess coagulation alterations in highlanders with or without EE using simple hemostatic tests such as bleeding (BT) and clotting (CT) times. Eighty-one male (43 ± 7 years), permanent residents from La Rinconada (Peru), the highest city in the world (5,100-5,300 m), were evaluated. Thirty-six subjects (44 %) presented with EE. EE subjects compared to non-EE subjects had lower BT (3.6 ± 1.2 vs. 7.0 ± 1.9 min, p < 0.001) and CT (11.7 ± 1.7 vs. 15.1 ± 2.3 min, p < 0.001). These results support the notion that highlanders with EE are in a state of hypercoagulability and call for further hemostasis investigations in this population using more detailed hemostatic methods.

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hal-03492482 , version 1 (08-09-2022)

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Ivan Hancco, Benoit Champigneulle, Emeric Stauffer, Aurélien Pichon, Paul Robach, et al.. Hemostasis in highlanders with excessive erythrocytosis at 5100 m: Preliminary data from the highest city of the world. Respiratory Physiology & Neurobiology, 2020, 282, pp.103535 -. ⟨10.1016/j.resp.2020.103535⟩. ⟨hal-03492482⟩
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