Apremilast in Combination with Narrowband UVB in the Treatment of Vitiligo: A 52-Week Monocentric Prospective Randomized Placebo-Controlled Study - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Investigative Dermatology Année : 2020

Apremilast in Combination with Narrowband UVB in the Treatment of Vitiligo: A 52-Week Monocentric Prospective Randomized Placebo-Controlled Study

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Background: Scientific rationale and encouraging first clinical results suggest the interest of using apremilast for treating vitiligo.Objective: This study aimed to compare the efficacy of apremilast in combination therapy with narrowband (NB)-UVB versus placebo and NB-UVB treatment for repigmentation in patients with nonsegmental vitiligo.Design: This was a 52-week prospective randomized placebo-controlled study.Participants: Adult patients with vitiligo participated.Interventions: Group A received, in addition to phototherapy, apremilast at the label dosage, and group B received placebo. After 24 weeks, patients who responded (decreased Vitiligo Area Scoring Index >30%) were rerandomized to receive apremilast or placebo, combined with twice-weekly NB-UVB for 24 additional weeks. Main outcome and measure: The primary outcome measure was the comparison between the two groups of the Vitiligo Area Scoring Index score at 24 weeks.Results: Eighty patients were randomized (40 in each group). After 24 weeks, the mean Vitiligo Area Scoring Index score decreased from 23.63 to 19.49 (P = 0.011) in the apremilast + UVB group and from 21.57 to 15.25 (P < 0.0001) in the placebo + UVB group. The difference between the two groups was not statistically significant (P = 0.18). No statistically significant differences were observed between the two groups after an additional 24 weeks of treatment.Conclusions and relevance: Apremilast does not bring any benefit to NB-UVB for treating vitiligo.Trial registration: ClinicalTrials.gov NCT03036995.
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hal-03492443 , version 1 (22-08-2022)

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Abdallah Khemis, Eric Fontas, Sophie Moulin, Henri Montaudié, Jean-Philippe Lacour, et al.. Apremilast in Combination with Narrowband UVB in the Treatment of Vitiligo: A 52-Week Monocentric Prospective Randomized Placebo-Controlled Study. Journal of Investigative Dermatology, 2020, 140, pp.1533 - 1537.e2. ⟨10.1016/j.jid.2019.11.031⟩. ⟨hal-03492443⟩
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