A comprehensive overview of promising biomarkers in stage II colorectal cancer - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cancer Treatment Reviews Année : 2020

A comprehensive overview of promising biomarkers in stage II colorectal cancer

Résumé

Colon cancer (CC) has the highest incidence rate among gastrointestinal cancers and ranks the third in mortality among all cancers, which contributes to the current CC burden and constitutes a major public health issue. While therapeutic strategies for stage I, III, and IV CC are standardized, those for stage II CC remain debatable. The choice of adjuvant chemotherapy for patients with stage II CC depends on stage (pT4) and grade (high) of the disease, the presence of venous, perinervous, and/or lymphatic emboli, or the need of suboptimal surgery (tumor with initial occlusion or perforation needing emergency surgeries, <12 lymph nodes harvested). Several prognostic factors that have been validated in retrospective studies can potentially define a population of CC patients at low and high-risk for reccurence. The role of biomarkers is becoming increasingly important for the future personalized treatment options. We conducted a systematic overview of potential prognostic biomarkers with possible clinical implications in stage II CC.
Fichier principal
Vignette du fichier
S0305737220300979.pdf (536.87 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03492180 , version 1 (15-07-2022)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Pauline Parent, Romain Cohen, Elie Rassy, Magali Svrcek, Julien Taieb, et al.. A comprehensive overview of promising biomarkers in stage II colorectal cancer. Cancer Treatment Reviews, 2020, 88, pp.102059 -. ⟨10.1016/j.ctrv.2020.102059⟩. ⟨hal-03492180⟩
25 Consultations
138 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More