Article Dans Une Revue Fitoterapia Année : 2020

Triterpenoid saponins from Calliandra calothyrsus Meisn. and their antiproliferative activity against two digestive carcinoma human cell lines

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The chemical investigation of the flowers and twigs of Calliandra calothyrsus (Fabaceae) led to the isolation of three new oleanane-type triterpenoid saponins, named calothyrsusosides AC (13). Their structures were established by direct interpretation of their spectral data, mainly HRESIMS, 1D NMR and 2D NMR (1H, 1H NMR DOSY, 13C NMR, COSY, HSQC, HMBC, HSQC-TOCSY and NOESY) and by comparison with literature data. Compounds 1 and 2 were tested for their antiproliferative activity against two digestive carcinoma human cell lines: Hep3B (hepatocellular carcinoma) and Caco-2 (epithelial colorectal adenocarcinoma). Both compounds exhibited an antiproliferative activity against the Hep3B cell line, with IC50 values of 6.0 and 6.5 μM, respectively, while no effect was detected against the epithelial colorectal adenocarcinoma Caco-2 (CC50 > 25 μM).

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Est complété par hal-04726040 Article Lin Marcellin Messi, Olivier Placide Noté, Joséphine Ngo Mbing, Pierre Lavedan, Marc Vedrenne, et al.. Corrigendum to “Triterpenoid saponins from Calliandra calothyrsus Meisn. and their antiproliferative activity against two digestive carcinoma human cell lines” [Fitoterapia volume 146 (2020) p1-9/article 104669]. Fitoterapia, 2024, 175, pp.105934. ⟨10.1016/j.fitote.2024.105934⟩. ⟨hal-04726040⟩

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hal-03490857 , version 1 (22-06-2022)

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Lin Marcellin Messi, Olivier Placide Noté, Joséphine Ngo Mbing, Pierre Lavedan, Marc Vedrenne, et al.. Triterpenoid saponins from Calliandra calothyrsus Meisn. and their antiproliferative activity against two digestive carcinoma human cell lines. Fitoterapia, 2020, 146, pp.104669 -. ⟨10.1016/j.fitote.2020.104669⟩. ⟨hal-03490857⟩
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