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Article Dans Une Revue Joint Bone Spine Année : 2019

Two-year abatacept retention rate in clinical practice in the French ACTION cohort

Résumé

Objectives: Abatacept retention rates were evaluated in the French cohort in the prospective ACTION study (2010-2013), which included patients with moderate-to-severe rheumatoid arthritis managed in everyday clinical practice and started on intravenous abatacept therapy. Methods: Two-year abatacept retention rates were evaluated in 455 patients classified according to treatment line, body mass index (BMI), and status for rheumatoid factor (RF) and anti-citrullinated peptide antibody (ACPA). Results: After 2 years, the overall abatacept retention rate was 44%. The retention rate was non-significantly higher in the patients with vs. without a history of unresponsiveness to at least one biologic (48.1% vs. 41.8%, respectively). No significant retention rate differences were found across BMI categories (444 patients; <25, 45.5%; ≥25 to <30, 48.9%; and ≥30, 36.6%). Neither were any significant differences demonstrated according to RF and ACPA status (RF+ and ACPA+, 45.7%; RF+ or ACPA+, 43.8%; and FR- and ACPA-, 39.1%). Conclusion: The 44% 2-year retention rate in the French ACTION cohort supports the usefulness of abatacept therapy. In this study, retention was not associated with treatment line, BMI, or antibody status.
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hal-03489017 , version 1 (21-12-2021)

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Xavier Mariette, Thierry Schaeverbeke, Philippe Gaudin, Mélanie Chartier, Julia Heitzmann, et al.. Two-year abatacept retention rate in clinical practice in the French ACTION cohort. Joint Bone Spine, 2019, 86 (6), pp.753 - 759. ⟨10.1016/j.jbspin.2019.07.006⟩. ⟨hal-03489017⟩
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