Article Dans Une Revue European Journal of Internal Medicine Année : 2019

Hereditary angioedema, emergency management of attacks by a call center

Eric Vicaut

Résumé

Objective: Hereditary angiœdema (HAE) is a rare autosomal dominant disease characterized by recurrent, unpredictable, potentially life-threatening swelling. Objective is to assess the management of the acute HAE attacks in the real life setting through a call center in France. Methods: A pre-specified ancillary study of SOS-HAE, a cluster-randomized prospective multicenter trial, was conducted. HAE patients were recruited from 8 participating reference centers. The outcome of interest was the rate of hospitalization. Results: onerhundred patients were included. The median (quartile) age was 38 (29-53) years, and 66 (66%) were female. Eighty (80%) patients had HAE type I, 8 (8%) had HAE type II and 12 (12%) patients had FXII-HAE. Fifty-one (51%) patients had experienced at least one time the call center during the follow-up. Nine over 166 (5%) attacks for 9 different patients resulted in hospital admission to the hospital (in the short-stay unit, ie, <24 h) during the follow-up period. During 2 years, there were 166 calls to call center for 166 attacks. All attacks were treated at home after call center contact. Conclusions: Use of emergency departments and hospitalizations are reduced by the use of a coordinated national call center in HAE after therapeutic education program that promoted self-administration of specific treatment and use of call to call center. Trial registration: clinicalTrials.gov identifier: NCT01679912.

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hal-03487717 , version 1 (20-07-2022)

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Nicolas Javaud, Adrien Altar, Olivier Fain, Paul-Georges Reuter, Michel Desmaizieres, et al.. Hereditary angioedema, emergency management of attacks by a call center. European Journal of Internal Medicine, 2019, 67, pp.42 - 46. ⟨10.1016/j.ejim.2019.05.007⟩. ⟨hal-03487717⟩
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