Structure-activity relationships of the N-methylcarbamate series in Salmonella typhimurium. - Archive ouverte HAL Access content directly
Journal Articles Mutation Research Letters Year : 1987

Structure-activity relationships of the N-methylcarbamate series in Salmonella typhimurium.

Abstract

Aromatic hydrocarbons of low molecular weight, hydroxy and N-methylcarbamate derivatives were tested for mutagenicity by the reversion of histidine-dependent Salmonella typhimurium TA98 and TA1535 in the presence of a rat-liver 9000 × g supernatant fraction. The presence of 2 or 3 aromatic rings resulted in a weak increase in revertants. Hydroxylation and carbamylation of aromatic rings increased the mutagenic activity of these aromatic compounds. In order to evaluate the structure-activity relationship, the specific molecular connectivity indices were calculated. A significant inverse relationship exist between mutagenicity and zero- and second-order specific molecular connectivity indices. Only compounds with second-order specific molecular connectivity indices lower than 0.300 increased mutagenic activity.
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Dates and versions

hal-03487086 , version 1 (17-12-2021)

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Jean-François Narbonne, Pierrette Cassand, P. Alzieu, P. Grolier, Georges Merlina, et al.. Structure-activity relationships of the N-methylcarbamate series in Salmonella typhimurium.. Mutation Research Letters, 1987, 191 (1), pp.21-27. ⟨10.1016/0165-7992(87)90165-5⟩. ⟨hal-03487086⟩
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