Nanocrystalline apatites in biological systems: characterisation, structure and properties. - Archive ouverte HAL Access content directly
Journal Articles Materials Science and Engineering Technology / Materialwissenschaft und Werkstofftechnik Year : 2007

Nanocrystalline apatites in biological systems: characterisation, structure and properties.

Abstract

Nanocrystalline apatitic calcium phosphates play a crucial role in calcified tissues and biomaterials. One of the most interesting characteristics of biomimetic apatite nanocrystals is the existence of a surface hydrated layer essentially related to their formation process in solution. This hydrated layer shows specific spectroscopic characteristics. It seems to exist in its nascent state only in wet samples and is altered on drying. This surface-hydrated layer progressively disappears as the stable apatite domains develop. The surface ions can be rapidly and reversibly exchanged in solution, mainly with selected bivalent species. The exchange reactions clearly reveal the existence of two domains: the relatively inert apatite core and the very reactive surface-hydrated domains. The structure of the hydrated layer has been shown to be reversibly affected by the constituting ions. Such a surface layer in bone apatite nanocrystals could participate actively in homeostasis and probably other regulation processes. The specificity of biomimetic apatite nanocrystals also opens interesting possibilities in materials science. The mobility of the mineral ions on the crystal surface, for example, allows strong bonding and interactions either with other crystals or with different substrates. Inter-crystalline interactions have been described as a “crystal fusion” process in vivo and they could be involved in the setting reaction of biomimetic calcium phosphate cements. Ceramic-like materials using the surface interaction capabilities of the nanocrystals can be produced at very low temperature (below 200 C). The surface-hydrated layer could also be involved in interactions with macromolecules and polymeric materials or in the coating of implants. The ion exchange and adsorption capabilities of the nanocrystals could probably be used for drug release, offering a range of possible behaviours.
Fichier principal
Vignette du fichier
rey_2630.pdf (237.41 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

hal-03481078 , version 1 (15-12-2021)

Identifiers

Cite

Christian Rey, Christèle Combes, Christophe Drouet, Albert Lebugle, Hocine Sfihi, et al.. Nanocrystalline apatites in biological systems: characterisation, structure and properties.. Materials Science and Engineering Technology / Materialwissenschaft und Werkstofftechnik, 2007, 38 (12), pp.996-1002. ⟨10.1002/mawe.200700229⟩. ⟨hal-03481078⟩
1 View
15 Download

Altmetric

Share

Gmail Facebook X LinkedIn More