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Article Dans Une Revue Journal of Neuroimmunology Année : 2019

Mass cytometry reveals an impairment of B cell homeostasis in anti-synthetase syndrome

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Recent data suggest the implication of T, B and NK cells in the anti-synthetase syndrome (ASyS); nevertheless their role and activation states are poorly described. We performed deep immune-profiling using 37 markers on peripheral blood cells from 10 ASyS patients versus 17 healthy donors (HD) and 26 myositis control patients. We show decreased percentages of memory B cells in ASyS patients (mean ± SEM: ASyS = 13 ± 3%, HD = 37 ± 4% and 'myositis controls' = 32 ± 3), counterbalanced by increased percentages of naïve B cells. Interestingly, perifascicular infiltrations of memory B cells within muscle biopsies of ASyS patients suggest that they niche within the muscle.
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hal-03477628 , version 1 (20-12-2021)

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Gaëlle Dzangué-Tchoupou, Yves Allenbach, Corinna Preusse, Werner Stenzel, Olivier Benveniste. Mass cytometry reveals an impairment of B cell homeostasis in anti-synthetase syndrome. Journal of Neuroimmunology, 2019, 332, pp.212 - 215. ⟨10.1016/j.jneuroim.2019.04.014⟩. ⟨hal-03477628⟩
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