Article Dans Une Revue Nucleic Acids Research Année : 2022

DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation

Rita Pancsa
Veronika Ács
Claudio Bassot
Norman E Davey
Laszlo Dobson
Arne Elofsson
Marian Novotný
Gabriele Pozzati
Martin Salas
Eva Schad
Aditi Shenoy
Nevena Veljkovic

Résumé

The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.

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hal-03463975 , version 1 (02-12-2021)

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Federica Quaglia, Bálint Mészáros, Edoardo Salladini, András Hatos, Rita Pancsa, et al.. DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation. Nucleic Acids Research, 2022, 50 (D1), pp.D480-D487. ⟨10.1093/nar/gkab1082⟩. ⟨hal-03463975⟩
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