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Article Dans Une Revue SynOpen Année : 2020

Challenging Atroposelective C–H Arylation

Résumé

Atropisomeric molecules are privileged scaffolds, not only as ligands for asymmetric synthesis, but also as biologically active products and advanced materials. Although very attractive from a sustainability viewpoint, the direct construction of the stereogenic axis through asymmetric C-H arylation is very challenging and consequently only a few examples have been reported. This short review summarizes these very recent results on the atropo-enantio or diastereoselective synthesis of atropisomeric (hetero)biaryl molecules; transformations during which the Ar-Ar atropisomeric axis is formed during the C-H activation process.

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Chimie
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Dates et versions

hal-03453872 , version 1 (28-11-2021)

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Joanna Wencel-Delord, Françoise Colobert. Challenging Atroposelective C–H Arylation. SynOpen, 2020, 04, pp.107 - 115. ⟨10.1055/s-0040-1705981⟩. ⟨hal-03453872⟩
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