Challenging Atroposelective C–H Arylation
Résumé
Atropisomeric molecules are privileged scaffolds, not only as ligands for asymmetric synthesis, but also as biologically active products and advanced materials. Although very attractive from a sustainability viewpoint, the direct construction of the stereogenic axis through asymmetric C-H arylation is very challenging and consequently only a few examples have been reported. This short review summarizes these very recent results on the atropo-enantio or diastereoselective synthesis of atropisomeric (hetero)biaryl molecules; transformations during which the Ar-Ar atropisomeric axis is formed during the C-H activation process.
Domaines
Chimie
Origine : Fichiers éditeurs autorisés sur une archive ouverte