The Industry 4.0 paradigm refers to a large set of technologies that will transform the way that the manufacturing industry will perform. Nowadays, those technologies and the potential benefits they offer are not fully understood and mastered by companies, and the propagation of the associated concepts is slow. However, in the past few years, some successful implementations of Industry 4.0-compliant technologies have been seen emerging in the literature. A systematic literature study has been conducted to identify the suggested methodologies for successful implementations. Following this analysis, identified patterns are synthesized as an implementation framework denoted as IPSI (Identification–Preparation–Simulation–Implementation). This framework was synthesized so as to be used for the first implementation of technologies in a company, thus increasing the chances of acceptability of those technologies. Three case studies, concerning three different technologies in three different manufacturing fields, were chosen to be confronted by the framework and its validity on the global manufacturing field is discussed.