IMMUNO-METABOLIC SIGNATURES OF DENDRITIC CELLS ASSOCIATE WITH T-CELL RESPONSES IN MELANOMA PATIENTS
Résumé
The therapeutic efficacy of Dendritic cells (DC)
vaccines remains low and there is an unmet need for more
effective vaccine design to achieve durable clinical outcomes.
Our study analyzed the transcriptomic and energetic metabolism
profile of an adenoviral-based DC vaccine targeted
against three commonly shared melanoma antigens: Tyrosinase,
MART-1 and MAGE-A6 from 35 subjects enrolled in a Phase
I study of autologous DC vaccines in late-stage melanoma.1
To further investigate the immuno-metabolic features of monocyte-
derived DC vaccines, we are employing a novel flow
cytometry-based method, called SCENITH2 to integrate functional
metabolic states with multiparametric DC immune
phenotypes.
Domaines
Sciences du Vivant [q-bio]| Origine | Fichiers éditeurs autorisés sur une archive ouverte |
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