Z -Selective Pd-catalyzed 2,2,2-trifluoroethylation of acrylamides at room temperature
Résumé
A straightforward 2,2,2-trifluoroethylation of acrylamides by Pd-catalyzed C–H bond activation was reported by using a fluorinated hypervalent iodine reagent as a coupling partner. At room temperature, this additive-free approach allowed the synthesis of Z-2,2,2-trifluoroethylated acrylamides (19 examples, up to 73% yield) in a stereoselective manner. Under these mild reaction conditions, the methodology turned out to be functional group tolerant and mechanistic studies gave us a better understanding of the transformation.
Domaines
Chimie| Origine | Fichiers produits par l'(les) auteur(s) |
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