The objective of the present work is to show the potential of in situ measurements 1 for the investigation of nanoparticles production in turbulent spray flames. This is achieved by 2 considering multiple diagnostics to characterize the liquid break-up, the reactive flow and the 3 particles production in a spray burner for TiO 2 nanoparticle synthesis. The considered liquid fuel 4 is a solution of isopropyl alcohol and titanium tetraisopropoxide (TTIP) precursor. Measurements 5 show that shadowgraphy can be used to simultaneously localize spray and nanoparticles, light 6 scattering allow to characterize the TiO 2 nanoparticles distribution in the flame central plane, 7 and spontaneous CH* and OH* chemiluminescences as well as global light emission results can 8 be used to visualize the reactive flow patterns that may differ with and without injection of 9 TTIP. Concerning the liquid, it is observed that is localized in a small region close to the injector 10 nozzle where it is dispersed by the oxygen flow resulting in droplets. The liquid droplets rapidly 11 evaporate and TTIP is quasi-immediately converted to TiO 2 nanoparticles. Finally, results show 12 high interactions between nanoparticles and the turbulent eddies.