Asymmetric Transfer Hydrogenation of gem ‐Difluorocyclopropenyl Esters: Access to Enantioenriched gem ‐Difluorocyclopropanes
Résumé
A catalytic enantioselective access to disubstituted functionalized gem-difluorocyclopropanes, which lie among emerging fluorinated motifs, was developed by asymmetric transfer hydrogenation of gem-difluorocyclopropenyl esters, catalyzed by Noyori-Ikariya (p-cymene)-ruthenium(II) complex, with (N-tosyl-1,2-diphenylethylenediamine) as chiral ligand and isopropanol as hydrogen donor. The resulting cis-gem-difluorocyclopropyl esters were obtained with moderate to high enantiomeric purities (ee = 66-99%) and post-functionalization reactions enable access to valuable building blocks incorporating a cis-or trans-gemdifluorocyclopropyl motif.
Domaines
ChimieOrigine | Fichiers produits par l'(les) auteur(s) |
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