Induction chemotherapy before surgery for unresectable head and neck cancer. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue B-ENT Année : 2016

Induction chemotherapy before surgery for unresectable head and neck cancer.

Résumé

Objective: To preoperatively reduce tumour size in patients with locally advanced and/or non-resectable squamous cell carcinoma with induction chemotherapy in order to achieve surgical excision with clear margins and preserve quality of life. Methodology: In this study, 16 patients with locally advanced and/or non-resectable squamous cell carcinoma underwent induction chemotherapy with docetaxel, cisplatin, and 5-fluorouricil or paclitaxel, carboplatin, and cetuximab. Results: Over 80% of patients responded to induction chemotherapy. Histological examination of the 14 surgical specimens showed a total absence of residual cancer cells in 37.5% of cases. Conclusion: Concurrent radiation and chemotherapy is the standard treatment for locally advanced head and neck squamous cell carcinoma; however, induction chemotherapy may be beneficial in select patients.

Domaines

Cancer
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Dates et versions

hal-03439029 , version 1 (22-01-2024)

Identifiants

  • HAL Id : hal-03439029 , version 1
  • PUBMED : 27097391

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H Schmaltz, C Borel, Saït Ciftci, C Takeda-Raguin, Christian Debry, et al.. Induction chemotherapy before surgery for unresectable head and neck cancer.. B-ENT, 2016, 12 (1), pp.29-32. ⟨hal-03439029⟩
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