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Article Dans Une Revue Cancers Année : 2021

Neoadjuvant concurrent radiotherapy and chemotherapy in early breast cancer patients: Long-term results of a prospective phase II trial

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Background: Neoadjuvant concurrent radiochemotherapy makes it possible to increase the breast conservation rate. This study reports the long term outcome of this treatment. Methods: From 2001 to 2003, 59 women with T2–3 N0–2 M0 invasive breast cancer (BC) not amenable to upfront breast conserving treatment (BCS) were included in this prospective, non-randomized phase II study. Chemotherapy (CT) consisted of four cycles of continuous 5-FU infusion and Vinorelbine. Starting concurrently with the second CT cycle, normofractionated RT was delivered to the breast and LN. Breast surgery was then performed. Results: Median follow-up (FU) was 13 years [3–18]. BCS was performed in 41 (69%) patients and mastectomy in 18 patients, with pathological complete response rate of 27%. Overall and distant-disease free survivals rates at 13 years were 70.9% [95% CI 59.6–84.2] and 71.5% [95% CI 60.5–84.5] respectively. Loco regional and local controls rates were 83.4% [95% CI 73.2–95.0] and 92.1% [95% CI 83.7–100], respectively. Late toxicity (CTCAE-V3) was assessed in 51 patients (86%) with a median follow-up of 13 years. Fifteen presented grade 2 fibrosis (29.4%), 8 (15.7%) had telangiectasia, and 1 had radiodermatitis. Conclusions: This combined treatment provided high long-term local control rates with limited side-effects.
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hal-03434964 , version 1 (31-05-2022)

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Diane Jornet, Pierre Loap, Jean Yves Pierga, Fatima Laki, Anne Vincent-Salomon, et al.. Neoadjuvant concurrent radiotherapy and chemotherapy in early breast cancer patients: Long-term results of a prospective phase II trial. Cancers, 2021, 13 (20), ⟨10.3390/cancers13205107⟩. ⟨hal-03434964⟩
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