Interplay Between Inhibitory Control and Behavioural Flexibility: Impact of Dorsomedial Striatal Dopamine Denervation in Mice - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Neuroscience Année : 2021

Interplay Between Inhibitory Control and Behavioural Flexibility: Impact of Dorsomedial Striatal Dopamine Denervation in Mice

Interactions entre contrôle inhibiteur et flexibilité comportementale: impact de la dénervation dopaminergique au niveau du striatum dorsomédian chez la souris

Résumé

In Parkinson's disease, nigrostriatal dopamine (DA) degeneration is commonly associated with motor symptomatology. However, non-motor symptoms affecting cognitive function, such as behavioural flexibility and inhibitory control may also appear early in the disease. Here we addressed the role of DA innervation of the dorsomedial striatum (DMS) in mediating these functions in 6-hydroxydopamine (6-OHDA)-lesioned mice using instrumental conditioning in various tasks. Behavioural flexibility was studied in a simple reversal task (nosepoke discrimination) or in reversal of a two-step sequence of actions (central followed by lateral nose-poke). Our results show that mild DA lesions of the DMS induces behavioural flexibility deficits in the sequential reversal learning only. In the first sessions following reversal of contingency, lesioned mice enhanced perseverative sequence of actions to the initial rewarded side then produced premature responses directly to the correct side omitting the central response, thus disrupting the two-step sequence of actions. These deficits may be linked to increased impulsivity as 6-OHDA-lesioned mice were unable to inhibit a previously learned motor response in a cued response inhibition task assessing proactive inhibitory control. Our findings show that partial DA denervation restricted to DMS impairs behavioural flexibility and proactive response inhibition in mice. Such striatal DA lesion may thus represent a valuable animal model for exploring deficits in executive control documented in early stage of Parkinson's disease.
Fichier principal
Vignette du fichier
Lhost_Neuroscience_2021.pdf (1.91 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03414568 , version 1 (04-11-2021)

Identifiants

Citer

Juliette Lhost, Isabelle Watabe, Didier Louber, Abdel-Mouttalib Ouagazzal, Martine Liberge, et al.. Interplay Between Inhibitory Control and Behavioural Flexibility: Impact of Dorsomedial Striatal Dopamine Denervation in Mice. Neuroscience, 2021, 477, pp.25 - 39. ⟨10.1016/j.neuroscience.2021.09.026⟩. ⟨hal-03414568⟩
49 Consultations
57 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More