Article Dans Une Revue Clinical Genitourinary Cancer Année : 2021

TAXOMET : A French prospective multicentric randomized controlled phase II study comparing docetaxel plus metformin versus docetaxel plus placebo in mCRPC

Werner Hilgers

Résumé

Background: Docetaxel (DOCE) is a standard of care in metastatic castration-resistant prostate cancer (mCRPC). Several retrospective studies suggested a decrease in Prostate Cancer incidence and mortality with metformin (MET). MET has also demonstrated anti-tumor activity in Prostate Cancer preclinical models, with increased apoptosis when added to DOCE. We aimed at exploring the role of MET in combination with DOCE in mCRPC. Patients and methods: Non-diabetic mCRPC patients were randomly assigned to receive DOCE 75 mg/m2 every 21 days + prednisone (5 mg. BID) with either MET 850 mg BID (D+M) or placebo (D+P) up to 10 cycles. Prostate-Specific Antigen (PSA) response ≥50% from baseline was the primary end point. Secondary end points included objective response rate (ORR), progression-free survival (PFS), overall survival (OS), toxicity and quality of life (QoL). Results: Out of 99 patients were randomized (D+M = 50; D+P = 49) in 10 French centers. The median follow-up was 86 (IQR 73-88) months. The PSA-response rate reached 66% in the D+M arm, but was not different from that observed in the D+P arm (63%, P = 0,94). In the D+M and D+P arms, the ORR was 28% and 24%, the median PFS was 7.8 and 6.0 months and the median OS was 27 and 20 months (ns), respectively. Diarrhea grade I to II was more frequent in the MET arm (66% vs. 43%). No impairment of QoL was observed. Conclusion: MET addition failed to improve the standard DOCE regimen in mCRPC. Further research targeting tumor cell metabolism should be performed.

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hal-03413458 , version 1 (03-11-2021)

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Marc Pujalte Martin, Delphine Borchiellini, Brice Thamphya, Aline Guillot, Jean-Baptiste Paoli, et al.. TAXOMET : A French prospective multicentric randomized controlled phase II study comparing docetaxel plus metformin versus docetaxel plus placebo in mCRPC. Clinical Genitourinary Cancer, 2021, ⟨10.1016/j.clgc.2021.08.008⟩. ⟨hal-03413458⟩
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