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Article Dans Une Revue Tetrahedron Année : 2005

Characterization of PEDOT film functionalized with a series of automated synthesis ferrocenyl-containing oligonucleotides

Résumé

In previous works we have described a fully automated synthesis of new ferrocene labelled oligonucleotides (Fc-ODNs) probes with one or more electroactive markers at different position in the chain. These Fc-ODNs have shown good properties to detect ODN target in solution. Here we describe the post-functionalization of a conducting co-polymer based on ethylenedioxythiophene (EDOT) derivatives by a series of Fc-ODNs. The grafting of the Fc-ODNs probes resulted in the appearance of the ferrocene redox couple which directly confirm the effectiveness of the ODN anchoring compared to traditional approach based on IR spectroscopy and X-ray fluorescence of the films. Moreover, the electrochemical response of the modified electrodes analysed in organic media before and after hybridization with ODN target confirm that properties obtain in solution for Fc-ODNs already exist in the film. The changes in the current intensity were found to be dependant on the structure of the grafted ODN that validate our strategy to synthesize an optimal Fc-ODNs.

Domaines

Chimie

Dates et versions

hal-03409069 , version 1 (29-10-2021)

Identifiants

Citer

Aude-Emmanuelle Navarro, Frédéric Fages, Corinne Moustrou, Hugues Brisset, Nicolas Spinelli, et al.. Characterization of PEDOT film functionalized with a series of automated synthesis ferrocenyl-containing oligonucleotides. Tetrahedron, 2005, 61 (16), pp.3947-3952. ⟨10.1016/j.tet.2005.02.058⟩. ⟨hal-03409069⟩
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