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Pré-Publication, Document De Travail Année : 2021

A Pan-Cancer Census of Dominant Tumor Immune Archetypes

Alexis Combes
Nayvin Chew
  • Fonction : Auteur
Peter Yan
  • Fonction : Auteur
Gabriella Reeder
Divyashree Kushnoor
  • Fonction : Auteur
Alan Shen
Brittany Davidson
Andrea Barczac
  • Fonction : Auteur
Michael Adkisson
  • Fonction : Auteur
Austin Edwards
  • Fonction : Auteur
Mohammad Naser
Kevin Barry
Tristan Courau
Taymour Hammoudi
Arjun Arkal Rao
Adam Olshen
Cathy Cai
  • Fonction : Auteur
Jenny Zhan
  • Fonction : Auteur
Katelyn Davis
  • Fonction : Auteur
Robin Kelley
Jocelyn Chapman
Chloe Attreya
  • Fonction : Auteur
Amar Patel
  • Fonction : Auteur
Adil Daud
Patrick Ha
Aaron Diaz
  • Fonction : Auteur
Johannes Kratz
Eric Collisson
  • Fonction : Auteur
Gabriela Fragiadakis
David Erle
Alexandre Boissonnas
Saurabh Asthana
  • Fonction : Auteur
Vincent Chan
Matthew Krummel

Résumé

SUMMARY Cancers display significant heterogeneity with respect to tissue of origin, driver mutations and other features of the surrounding tissue. It is likely that persistent tumors differentially engage inherent patterns–here ‘Archetypes’–of the immune system, to both benefit from a tumor immune microenvironment (TIME) and to disengage tumor-targeting. To discover dominant immune system archetypes, the Immunoprofiler Initiative (IPI) processed 364 individual tumors across 12 cancer types using standardized protocols. Computational clustering of flow cytometry and transcriptomic data obtained from cell sub compartments uncovered archetypes that exist across indications. These Immune composition-based archetypes differentiate tumors based upon unique immune and tumor gene-expression patterns. Archetypes discovered this way also tie closely to well-established classifications of tumor biology. The IPI resource provides a template for understanding cancer immunity as a collection of dominant patterns of immune infiltration and provides a rational path forward to learn how to modulate these patterns to improve therapy.

Domaines

Immunologie Cancer

Dates et versions

hal-03407890 , version 1 (28-10-2021)

Identifiants

Citer

Rafael J Argüello, Alexis Combes, Bushra Samad, Jessica Tsui, Nayvin Chew, et al.. A Pan-Cancer Census of Dominant Tumor Immune Archetypes. 2021. ⟨hal-03407890⟩

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CNRS UNIV-AMU
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