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Journal Articles The international journal of biostatistics Year : 2022

Spike detection for calcium activity


We present in this paper a global methodology for the spike detection in a biological context of fluorescence recording of GnRh-neurons calcium activity. For this purpose we first propose a simple stochastic model that could mimic experimental time series by considering an autoregressive AR(1) process with a linear trend and specific innovations involving spiking times. Estimators of parameters with asymptotic normality are established and used to set up a statistical test on estimated innovations in order to detect spikes. We compare several procedures and illustrate on biological data the performance of our procedure.
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Dates and versions

hal-02370401 , version 1 (19-11-2019)
hal-02370401 , version 2 (05-06-2020)
hal-02370401 , version 3 (08-12-2022)



Hermine Biermé, Camille Constant, Anne Duittoz, Christine Georgelin. Spike detection for calcium activity. The international journal of biostatistics, 2022, ⟨10.1515/ijb-2020-0043⟩. ⟨hal-02370401v3⟩
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