Local and systemic factors drive ectopic osteogenesis in regenerating muscles of spinal-cord-injured mice in a lesion-level-dependent manner - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Neurotrauma Année : 2021

Local and systemic factors drive ectopic osteogenesis in regenerating muscles of spinal-cord-injured mice in a lesion-level-dependent manner

Résumé

Neuroimmune dysfunction is thought to promote the development of several acute and chronic complications in spinal cord injury (SCI) patients. Putative roles for adrenal stress hormones and catecholamines are increasingly being recognized, yet how these adversely affect peripheral tissue homeostasis and repair under SCI conditions remains elusive. Here, we investigated their influence in a mouse model of SCI with acquired neurogenic heterotopic ossification. We show that spinal cord lesions differentially influence muscular regeneration in a level-dependent manner and through a complex multi-step process that creates an osteopermissive environment within the first hours of injury. This cascade of events is shown to critically involve adrenergic signals and drive the acute release of the neuropeptide, substance P. Our findings generate new insights into the kinetics and processes that govern SCI-induced deregulations in skeletal muscle homeostasis and regeneration, thereby aiding the development of sequential therapeutic strategies that can prevent or attenuate neuromusculoskeletal complications in SCI patients.
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Dates et versions

hal-03401844 , version 1 (25-10-2021)

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Charlotte Debaud, Hsu Wen Tseng, Malha Chedik, Irina Kulina, François Genêt, et al.. Local and systemic factors drive ectopic osteogenesis in regenerating muscles of spinal-cord-injured mice in a lesion-level-dependent manner. Journal of Neurotrauma, 2021, 38 (15), pp.2162-2175. ⟨10.1089/neu.2021.0058⟩. ⟨hal-03401844⟩
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