A Water‐Soluble Peptoid Chelator that Can Remove Cu 2+ from Amyloid‐β Peptides and Stop the Formation of Reactive Oxygen Species Associated with Alzheimer's Disease - Archive ouverte HAL Access content directly
Journal Articles Angewandte Chemie International Edition Year : 2021

A Water‐Soluble Peptoid Chelator that Can Remove Cu 2+ from Amyloid‐β Peptides and Stop the Formation of Reactive Oxygen Species Associated with Alzheimer's Disease

Abstract

Cu-chelation from amyloid-β (Aβ) peptide complexes is a known approach towards the development of therapeutics for Alzheimer's disease (AD), the most common form of dementia. Herein we describe a water-soluble peptidomimetic chelator that removes Cu from Cu–Aβ in the presence of Zn, forming the thermodynamically stable Cu–chelator complex, and by this enables the inhibition of ROS production in a reducing environment at physiological pH.
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Dates and versions

hal-03395343 , version 1 (22-10-2021)

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Anastasia E Behar, Laurent Sabater, Maria Baskin, Christelle Hureau, Galia Maayan. A Water‐Soluble Peptoid Chelator that Can Remove Cu 2+ from Amyloid‐β Peptides and Stop the Formation of Reactive Oxygen Species Associated with Alzheimer's Disease. Angewandte Chemie International Edition, 2021, 60 (46), pp.24588-24597. ⟨10.1002/anie.202109758⟩. ⟨hal-03395343⟩
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