A Water‐Soluble Peptoid Chelator that Can Remove Cu 2+ from Amyloid‐β Peptides and Stop the Formation of Reactive Oxygen Species Associated with Alzheimer's Disease
Résumé
Cu-chelation from amyloid-β (Aβ) peptide complexes is a known approach towards the development of therapeutics for Alzheimer's disease (AD), the most common form of dementia. Herein we describe a water-soluble peptidomimetic chelator that removes Cu from Cu–Aβ in the presence of Zn, forming the thermodynamically stable Cu–chelator complex, and by this enables the inhibition of ROS production in a reducing environment at physiological pH.
Domaines
Chimie de coordination| Origine | Fichiers produits par l'(les) auteur(s) |
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