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Article Dans Une Revue Biological Psychiatry Année : 2015

Presynaptic D2 Dopamine Receptors Control LTD Expression and Memory Processes in the Temporal Hippocampus

Résumé

Dysfunctional mesocorticolimbic dopamine signaling has been linked to alterations in motor and reward-based functions associated with psychiatric disorders. Converging evidence from patients with psychiatric disorders and use of antipsychotics suggests that imbalance of dopamine signaling deeply alters hippocampal functions. However, given the lack of full characterization of a functional mesohippocampal pathway, the precise role of dopamine transmission in memory deficits associated with these disorders and their dedicated therapies is unknown. In particular, the positive outcome of antipsychotic treatments, commonly antagonizing D2 dopamine receptors (D2Rs), on cognitive deficits and memory impairments remains questionable.
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hal-03389601 , version 1 (09-11-2021)

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Jill Rocchetti, Elsa Isingrini, Gregory Dal Bo, Sara Sagheby, Aurore Menegaux, et al.. Presynaptic D2 Dopamine Receptors Control LTD Expression and Memory Processes in the Temporal Hippocampus. Biological Psychiatry, 2015, 77 (6), pp.513-525. ⟨10.1016/j.biopsych.2014.03.013⟩. ⟨hal-03389601⟩
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