Evaluating optimal strategies for electric field dosimetry from intracranial electrodes
Résumé
Intracranial electrodes are used clinically for diagnostic (e.g. in drug-refractory epilepsy) or therapeutic (deep brain stimulation, e.g. epilepsy) purposes. Electrical stimulation delivered through such electrodes is key to understand how the resulting electric fields modulate neuronal (hyper)excitability. However, quantifying such fields in a patient-specific way is challenging, since etiology impacts brain anatomy (morphology) and biophysical properties (e.g., conductivity). Here, we evaluate how to approximate the electric fields from intracranial electrodes used clinically. Those results are the first step towards computationally tractable, patient-specific models of electric fields generated during neuromodulation protocols.
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