Immunological exhaustion: How to make a disparate concept operational? - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue PLoS Pathogens Année : 2021

Immunological exhaustion: How to make a disparate concept operational?

Hannah Kaminski
Maël Lemoine

Résumé

In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, for experimental and therapeutic purposes, to clarify these approaches and their interconnections so as to make the concept of exhaustion genuinely operational.
Fichier principal
Vignette du fichier
Kaminski-Lemoine-Pradeu_Immunological exhaustion_PLoS Path_Final draft.pdf (907.3 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03386389 , version 1 (19-10-2021)

Identifiants

Citer

Hannah Kaminski, Maël Lemoine, Thomas Pradeu. Immunological exhaustion: How to make a disparate concept operational?. PLoS Pathogens, 2021, 17 (9), pp.e1009892. ⟨10.1371/journal.ppat.1009892⟩. ⟨hal-03386389⟩

Collections

CNRS HIPHISCITECH
11 Consultations
37 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More