Stereoselective synthesis of enantiopure analogues of (−)-cephalotaxine - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Tetrahedron: Asymmetry Année : 2010

Stereoselective synthesis of enantiopure analogues of (−)-cephalotaxine

Résumé

The asymmetric total synthesis of three analogues of ()-cephalotaxine with structural modification of the aromatic ring was achieved in 16 steps and acceptable overall yields. The procedure used was quite similar to that reported by our group for the total synthesis of ()-cephalotaxine in 2004. The enantiopure spiranic compound 4 is a common intermediate on which various aromatic groups can be introduced. Unexpected and interesting different chemical behaviors were observed during these syntheses.
Fichier principal
Vignette du fichier
tet asymmetry 2010.pdf (183.38 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03386006 , version 1 (19-10-2021)

Identifiants

Citer

Farouk Berhal, Joelle Pérard-Viret, Jacques Royer. Stereoselective synthesis of enantiopure analogues of (−)-cephalotaxine. Tetrahedron: Asymmetry, 2010, 21 (3), pp.325-332. ⟨10.1016/j.tetasy.2010.01.004⟩. ⟨hal-03386006⟩
10 Consultations
27 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More