Stereoselective synthesis of enantiopure analogues of (−)-cephalotaxine
Résumé
The asymmetric total synthesis of three analogues of ()-cephalotaxine with structural modification of
the aromatic ring was achieved in 16 steps and acceptable overall yields. The procedure used was quite
similar to that reported by our group for the total synthesis of ()-cephalotaxine in 2004. The enantiopure spiranic compound 4 is a common intermediate on which various aromatic groups can be introduced. Unexpected and interesting different chemical behaviors were observed during these syntheses.
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