Synthesis and evaluation of substituted indolizidines as peptidomimetics of RGD tripeptide sequence
Résumé
The synthesis of seven peptidomimetics of RGD is presented. The indolizidine building block was obtained
by condensation of allylglycine with dimethoxydihydrofuran followed by an intermolecular cyclization.
The bicyclic ring was functionalised with a carboxylic acid and a guanidinium appendage. The
seven peptidomimetics were evaluated by cell-adhesion assays
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