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Article Dans Une Revue Tetrahedron Année : 2009

Synthesis and evaluation of substituted indolizidines as peptidomimetics of RGD tripeptide sequence

Résumé

The synthesis of seven peptidomimetics of RGD is presented. The indolizidine building block was obtained by condensation of allylglycine with dimethoxydihydrofuran followed by an intermolecular cyclization. The bicyclic ring was functionalised with a carboxylic acid and a guanidinium appendage. The seven peptidomimetics were evaluated by cell-adhesion assays
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hal-03385010 , version 1 (19-10-2021)

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Joelle Pérard-Viret, Delphine Halie, Sylvie Dufour, Jacques Royer. Synthesis and evaluation of substituted indolizidines as peptidomimetics of RGD tripeptide sequence. Tetrahedron, 2009, 65 (7), pp.1402-1414. ⟨10.1016/j.tet.2008.12.015⟩. ⟨hal-03385010⟩

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