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Journal Articles Developmental Dynamics Year : 2015

New insights in the clockwork mechanism regulating lineage specification: Lessons from the Drosophila nervous system

Abstract

Powerful transcription factors called fate determinants induce robust differentiation programs in multipotent cells and trigger lineage specification. These factors guarantee the differentiation of specific tissues/organs/cells at the right place and the right moment to form a fully functional organism. Fate determinants are activated by temporal, positional, epigenetic, and post-transcriptional cues, hence integrating complex and dynamic developmental networks. In turn, they activate specific transcriptional/epigenetic programs that secure novel molecular landscapes.

Dates and versions

hal-03376924 , version 1 (13-10-2021)

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Pierre Cattenoz, Angela Giangrande. New insights in the clockwork mechanism regulating lineage specification: Lessons from the Drosophila nervous system. Developmental Dynamics, 2015, 244 (3), pp.332-341. ⟨10.1002/dvdy.24228⟩. ⟨hal-03376924⟩
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