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Article Dans Une Revue European Journal of Clinical Microbiology and Infectious Diseases Année : 2021

Characteristics and outcome of varicella-zoster virus central nervous system infections in adults

P Fillâtre
  • Fonction : Auteur

Résumé

We conducted an observational retrospective study of all adults hospitalized for documented varicella-zoster virus (VZV) meningitis or encephalitis during years 2000-2015 in one referral centre. Thirty-six patients (21 males, 15 females) were included, with meningitis (n = 21), or meningoencephalitis (n = 15). Median age was 51 years [interquartile range, 35-76], and 6 patients (17%) were immunocompromised. Aciclovir was started in 32 patients (89%), with a median dose of 11 mg/kg/8 h [10-15]. No patient died, but 12 (33%) had neurological sequelae at discharge. Age was the only variable associated with adverse outcome (OR 1.98 [1.17-3.35] per 10-year increment, P = 0.011).
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Dates et versions

hal-03372911 , version 1 (11-10-2021)

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A Le Bot, A Ballerie, C Pronier, F Bénézit, F Reizine, et al.. Characteristics and outcome of varicella-zoster virus central nervous system infections in adults. European Journal of Clinical Microbiology and Infectious Diseases, 2021, 40 (11), pp.2437-2442. ⟨10.1007/s10096-021-04245-y⟩. ⟨hal-03372911⟩
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