Hypothalamic Regulation of Glucose Homeostasis: Is the Answer in the Matrix?
Résumé
Neurons within the arcuate nucleus control energy balance and represent the functional substrates through which FGF1 deploys its anti-diabetic action. Alonge et al., (2020) now reports that the integrity of arcuate perineuronal nets, an extracellular matrix component that enmesh GABAergic neurons, is reversibly altered in diabetic rats, and a key component for FGF1-mediated diabetic remission. These novel insights unravel how perineuronal nets dynamically contribute to the central control of glycemia.
Domaines
Sciences du Vivant [q-bio]
Fichier principal
Cell Metab Preview 2020-SL1-RL1 accepted manuscript.pdf (381.67 Ko)
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Cell Metab Matrix.pdf (1.02 Mo)
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Origine : Fichiers produits par l'(les) auteur(s)
Origine : Fichiers produits par l'(les) auteur(s)