Enterprises now face a global, dynamic, and unpredictable economic environment. In response to quick changes of the demand, the production needs to have the ability to adapt rapidly to meet the production requirements. The Reconfigurable Manufacturing System (RMS) paradigm enables such capabilities. However, defining design and reconfiguration rules is highly challenging, as it requires a broad knowledge encompassing the inclusion of technological, production, and economic metrics, as well as an understanding of a reconfiguration strategy, determining the necessary reconfiguration frequency of the system. For now, no global methodology taking all those aspects into account has been proposed. This article presents an original framework for the design, evaluation, and reconfiguration of the Reconfigurable Production System (RPS). New metrics to measure reconfigurability are defined. The design approach consists in three main steps which are individually developed. The selection of the appropriated production system is based on the comparison of reconfigurability and productivity indicators. Finally, the reconfiguration strategy is presented. The methodology is applied on a case study from the automotive industry.