One pot synthesis of α-amino nitrile units through alkylative Strecker cyanation from formamides
Résumé
We describe herein the one-pot synthesis of α-amino nitrile units by the concomitant addition of alkyl (or aryl) Grignard reagents and TMS cyanide through alkylative Strecker cyanation from readily available formamides. The reaction is broad in scope and the conditions are mild, inexpensive and easy to set-up, providing numerous α-amino nitriles in good yields (34 examples, 41-94% yield).
Domaines
Chimie
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