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Article Dans Une Revue European Journal of Organic Chemistry Année : 2021

One pot synthesis of α-amino nitrile units through alkylative Strecker cyanation from formamides

Résumé

We describe herein the one-pot synthesis of α-amino nitrile units by the concomitant addition of alkyl (or aryl) Grignard reagents and TMS cyanide through alkylative Strecker cyanation from readily available formamides. The reaction is broad in scope and the conditions are mild, inexpensive and easy to set-up, providing numerous α-amino nitriles in good yields (34 examples, 41-94% yield).

Domaines

Chimie
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hal-03366205 , version 1 (05-10-2021)

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Bao Yu, Florent Bodinier, Maximiliene Saague‐tenefo, Patrice Gerardo, Janick Ardisson, et al.. One pot synthesis of α-amino nitrile units through alkylative Strecker cyanation from formamides. European Journal of Organic Chemistry, 2021, 2021 (25), pp.3634-3640. ⟨10.1002/ejoc.202100418⟩. ⟨hal-03366205⟩
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