Low-valent dialkoxytitanium(II): a useful tool for the synthesis of functionalized seven-membered ring compounds - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Chemical Communications Année : 2021

Low-valent dialkoxytitanium(II): a useful tool for the synthesis of functionalized seven-membered ring compounds

Résumé

Herein, we describe unprecedented access to all-carbon or heterocyclic seven-membered ring frameworks from 1,8-ene-ynes promoted by inexpensive low-valent titanium(II) species, readily available from Ti(OiPr)4 and Grignard reagent. A broad range of cycloheptane, azepane or oxepane derivatives has been obtained (19 examples) with moderate to good yields and an excellent selectivity (up to 95/5 d.r.).
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hal-03366094 , version 1 (05-10-2021)

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Florent Bodinier, Youssouf Sanogo, Janick Ardisson, Marie-Isabelle Lannou, Geoffroy Sorin. Low-valent dialkoxytitanium(II): a useful tool for the synthesis of functionalized seven-membered ring compounds. Chemical Communications, 2021, 57 (29), pp.3603-3606. ⟨10.1039/d1cc00081k⟩. ⟨hal-03366094⟩
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