Sodium background currents in endocrine/neuroendocrine cells: towards unraveling channel identity and contribution in hormone secretion - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue (Article De Synthèse) Frontiers in Neuroendocrinology Année : 2021

Sodium background currents in endocrine/neuroendocrine cells: towards unraveling channel identity and contribution in hormone secretion

Résumé

In endocrine/neuroendocrine tissues, excitability of secretory cells is patterned by the repertoire of ion channels and there is clear evidence that extracellular sodium (Na+) ions contribute to hormone secretion. While voltage-gated channels involved in action potential generation are well-described, the background 'leak' channels operating near the resting membrane potential are much less known, and in particular the channels supporting a background entry of Na+ ions. These background Na+ currents (called here 'INab') have the ability to modulate the resting membrane potential and subsequently affect action potential firing. Here we compile and analyze the data collected from three endocrine/neuroendocrine tissues: the anterior pituitary gland, the adrenal medulla and the endocrine pancreas. We also model how INab can be functionally involved in cellular excitability. Finally, towards deciphering the physiological role of INab in endocrine/neuroendocrine cells, its implication in hormone release is also discussed.
Fichier principal
Vignette du fichier
Guerineau et al-Front Neuroendocrinol-2021.pdf (2.38 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03364483 , version 1 (04-10-2021)

Identifiants

Citer

Nathalie C. Guérineau, Arnaud Monteil, Philippe Lory. Sodium background currents in endocrine/neuroendocrine cells: towards unraveling channel identity and contribution in hormone secretion. Frontiers in Neuroendocrinology, 2021, 63, pp.100947. ⟨10.1016/j.yfrne.2021.100947⟩. ⟨hal-03364483⟩
92 Consultations
109 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More