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Article Dans Une Revue eLife Année : 2021

APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population

Angela Garcia
  • Fonction : Auteur
Caleb Finch
  • Fonction : Auteur
Margaret Gatz
  • Fonction : Auteur
Thomas S. Kraft
  • Fonction : Auteur
Daniel Eid Rodriguez
  • Fonction : Auteur
Daniel Cummings
  • Fonction : Auteur
Mia Charifson
  • Fonction : Auteur
Kenneth Buetow
  • Fonction : Auteur
Bret A. Beheim
  • Fonction : Auteur
Hooman Allayee
  • Fonction : Auteur
Gregory Thomas
  • Fonction : Auteur
Michael Gurven
Hillard Kaplan
  • Fonction : Auteur
Benjamin C. Trumble
  • Fonction : Auteur

Résumé

In post-industrial settings, apolipoprotein E4 (APOE4) is associated with increased cardiovascular and neurological disease risk. However, the majority of human evolutionary history occurred in environments with higher pathogenic diversity and low cardiovascular risk. We hypothesize that in high-pathogen and energy-limited contexts, the APOE4 allele confers benefits by reducing innate inflammation when uninfected, while maintaining higher lipid levels that buffer costs of immune activation during infection. Among Tsimane forager-farmers of Bolivia (N = 1266, 50% female), APOE4 is associated with 30% lower C-reactive protein, and higher total cholesterol and oxidized LDL. Blood lipids were either not associated, or negatively associated with inflammatory biomarkers, except for associations of oxidized LDL and inflammation which were limited to obese adults. Further, APOE4 carriers maintain higher levels of total and LDL cholesterol at low body mass indices (BMIs). These results suggest that the relationship between APOE4 and lipids may be beneficial for pathogen-driven immune responses and unlikely to increase cardiovascular risk in an active subsistence population.
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Dates et versions

hal-03364139 , version 1 (04-10-2021)

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Angela Garcia, Caleb Finch, Margaret Gatz, Thomas S. Kraft, Daniel Eid Rodriguez, et al.. APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population. eLife, 2021, 10:e68231, pp.1-20. ⟨10.7554/eLife.68231⟩. ⟨hal-03364139⟩

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