Neurotoxicité chez la souris de portions riches en cystéines des protéines Tat du virus visna et de VIH-1 - Archive ouverte HAL Access content directly
Journal Articles Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie Year : 1990

[Neurotoxicity in mice due to cysteine-rich parts of visna virus and HIV-1 Tat proteins]

Neurotoxicité chez la souris de portions riches en cystéines des protéines Tat du virus visna et de VIH-1

Isabelle Gourdou
  • Function : Author
Kamel Mabrouk
  • Function : Author
Gordon Harkiss
  • Function : Author
Neil Watt
  • Function : Author
Francis Hery
  • Function : Author
Robert Vigne
  • Function : Author

Abstract

The trans-activating visna virus and HIV-1 Tat proteins share, at their amino-acid sequence level, a significant 60% analogy on 17 consecutive residues. These homologous sequences are also found in a part of the short neurotoxin sequence from snake venom. Synthetic peptides representative of the two analogous viral sequences are, after intracerebroventricular injection at doses of 200 micrograms per 20 g mouse, responsible for the death of the injected animal in few hours. The HIV-1 recombinant Tat protein has the same effect. Such observation suggests a direct role of the Tat lentiviral protein in the origin of the neurologic effects associated with visna and HIV-1 infections.
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Dates and versions

hal-03363668 , version 1 (04-10-2021)

Identifiers

  • HAL Id : hal-03363668 , version 1
  • PUBMED : 2169973

Cite

Isabelle Gourdou, Kamel Mabrouk, Gordon Harkiss, Pascale Marchot, Neil Watt, et al.. Neurotoxicité chez la souris de portions riches en cystéines des protéines Tat du virus visna et de VIH-1. Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie, 1990, 311 (4), pp.149-55. ⟨hal-03363668⟩

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