Neurotoxicité chez la souris de portions riches en cystéines des protéines Tat du virus visna et de VIH-1 - Archive ouverte HAL Access content directly
Journal Articles Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie Year : 1990

[Neurotoxicity in mice due to cysteine-rich parts of visna virus and HIV-1 Tat proteins]

Neurotoxicité chez la souris de portions riches en cystéines des protéines Tat du virus visna et de VIH-1

I Gourdou
  • Function : Author
K Mabrouk
  • Function : Author
G Harkiss
  • Function : Author
P. Marchot
N Watt
  • Function : Author
F Hery
  • Function : Author
R Vigne
  • Function : Author

Abstract

The trans-activating visna virus and HIV-1 Tat proteins share, at their amino-acid sequence level, a significant 60% analogy on 17 consecutive residues. These homologous sequences are also found in a part of the short neurotoxin sequence from snake venom. Synthetic peptides representative of the two analogous viral sequences are, after intracerebroventricular injection at doses of 200 micrograms per 20 g mouse, responsible for the death of the injected animal in few hours. The HIV-1 recombinant Tat protein has the same effect. Such observation suggests a direct role of the Tat lentiviral protein in the origin of the neurologic effects associated with visna and HIV-1 infections.
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Dates and versions

hal-03363668 , version 1 (04-10-2021)

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  • HAL Id : hal-03363668 , version 1
  • PUBMED : 2169973

Cite

I Gourdou, K Mabrouk, G Harkiss, P. Marchot, N Watt, et al.. Neurotoxicité chez la souris de portions riches en cystéines des protéines Tat du virus visna et de VIH-1. Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie, 1990, 311 (4), pp.149-55. ⟨hal-03363668⟩

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