The serum metabolome mediates the concert of diet, exercise, and neurogenesis, determining the risk for cognitive decline and dementia - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Alzheimer's & Dementia : the Journal of the Alzheimer's Association Année : 2021

The serum metabolome mediates the concert of diet, exercise, and neurogenesis, determining the risk for cognitive decline and dementia

Cécile Delcourt
Cecile Proust-Lima

Résumé

Introduction: Diet and exercise influence the risk of cognitive decline (CD) and dementia through the food metabolome and exercise-triggered endogenous factors, which use the blood as a vehicle to communicate with the brain. These factors might act in concert with hippocampal neurogenesis (HN) to shape CD and dementia. Methods: Using an in vitro neurogenesis assay, we examined the effects of serum samples from a longitudinal cohort (n = 418) on proxy HN readouts and their association with future CD and dementia across a 12-year period. Results: Altered apoptosis and reduced hippocampal progenitor cell integrity were associated with exercise and diet and predicted subsequent CD and dementia. The effects of exercise and diet on CD specifically were mediated by apoptosis. Discussion: Diet and exercise might influence neurogenesis long before the onset of CD and dementia. Alterations in HN could signify the start of the pathological process and potentially represent biomarkers for CD and dementia.
Fichier principal
Vignette du fichier
BPH_AD_2021_Du-Preez.pdf (6.1 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03361323 , version 1 (01-10-2021)

Licence

Paternité

Identifiants

Citer

Andrea Du Preez, Sophie Lefevre Arbogast, Vikki Houghton, Chiara de Lucia, Dorrain Y. Low, et al.. The serum metabolome mediates the concert of diet, exercise, and neurogenesis, determining the risk for cognitive decline and dementia. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2021, ⟨10.1002/alz.12428⟩. ⟨hal-03361323⟩
188 Consultations
26 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More