Aqueous ROPISA of α-amino acid N-carboxyanhydrides: polypeptide block secondary structure controls nanoparticle shape anisotropy - Archive ouverte HAL Access content directly
Journal Articles Polymer Chemistry Year : 2021

Aqueous ROPISA of α-amino acid N-carboxyanhydrides: polypeptide block secondary structure controls nanoparticle shape anisotropy

Mark Grinstaff

Abstract

Polymerization-induced self-assembly (PISA) is an efficient one-step process to obtain nanomaterials. In this work, aqueous ring-opening polymerization induced self-assembly (ROPISA) of α-amino acid N-carboxyanhydride (NCA) affords controllable well-defined nanoassemblies. ROPISA with the PEG5 kDa-NH2 macroinitiator and either the benzyl-L-glutamate NCA (BLGNCA) or L-leucine NCA (LeuNCA) monomer yields amphiphilic block copolymers, with different polypeptide molar masses, which spontaneously form nanostructures. In contrast to the previous PISA process where the hydrophobic to hydrophilic ratio was the main parameter defining nanomaterial morphology, the secondary structure of the polypeptides is the main driving force to stabilize the anisotropic rod-like nanostructures with this ROPISA process.

Domains

Polymers
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Dates and versions

hal-03359087 , version 1 (30-09-2021)

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Chloé Grazon, Pedro Salas-Ambrosio, Ségolène Antoine, Emmanuel Ibarboure, Olivier Sandre, et al.. Aqueous ROPISA of α-amino acid N-carboxyanhydrides: polypeptide block secondary structure controls nanoparticle shape anisotropy. Polymer Chemistry, 2021, 12 (43), pp.6242-6251. ⟨10.1039/D1PY00995H⟩. ⟨hal-03359087⟩
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