Article Dans Une Revue Physical Chemistry Chemical Physics Année : 2021

The structure of isolated thalidomide as reference for its chirality-dependent biological activity: a laser-ablation rotational study

Résumé

Using the gas-phase structure of laser-ablated thalidomide as reference confirms the high distortion of the ( R )-enantiomer bound to cereblon in agreement with the enhanced teratogenicity of the ( S ) enantiomer.

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Dates et versions

hal-03352744 , version 1 (23-09-2021)

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Susana Blanco, Alberto Macario Farto, Juan Carlos López. The structure of isolated thalidomide as reference for its chirality-dependent biological activity: a laser-ablation rotational study. Physical Chemistry Chemical Physics, 2021, 23 (24), pp.13705-13713. ⟨10.1039/D1CP01691A⟩. ⟨hal-03352744⟩
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