Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cell Metabolism Année : 2019

Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits

Asma Oummadi
  • Fonction : Auteur
  • PersonId : 1327608
  • IdRef : 273447408
Tarson Tolentino-Cortez
  • Fonction : Auteur
Lucy Martine
  • Fonction : Auteur
Stephane Gregoire
  • Fonction : Auteur
  • PersonId : 1157002
Stephanie Cabaret
  • Fonction : Auteur
Sophie Layé
Jing Xuan Kang
  • Fonction : Auteur
Olivier Berdeaux
Gabriel Barreda-Gomez
  • Fonction : Auteur
Elodie A.Y. Masson
David W. L. Ma
  • Fonction : Auteur

Résumé

Reward-processing impairment is a common symptomatic dimension of several psychiatric disorders. However, whether the underlying pathological mechanisms are common is unknown. Herein, we asked if the decrease in the n-3 Polyunsaturated Fatty Acids (PUFAs) lipid species, consistently described in these pathologies, could underlie reward-processing deficits. We show that reduced n-3 PUFA biostatus in mice leads to selective motivational deficits. Electrophysiological recordings revealed increased collateral inhibition of dopamine D2 receptor (D2R)-expressing medium spiny neurons (iMSNs) onto dopamine D1 receptor-expressing (d)MSNs in the nucleus accumbens, a main brain region for the modulation of motivation. Strikingly, transgenically preventing n-3 PUFA deficiency selectively in D2R-expressing neurons normalizes MSNs collateral inhibition and enhances motivation. These results constitute the first demonstration of a causal link between a behavioral deficit and n-3 PUFA decrease in a discrete neuronal population and suggest that lower n-3 PUFA biostatus in psychopathologies could participate to the etiology of reward-related symptoms.
Fichier non déposé

Dates et versions

hal-03347311 , version 1 (17-09-2021)

Identifiants

Citer

Fabien Ducrocq, Roman Walle, Andrea Contini, Asma Oummadi, Baptiste Caraballo, et al.. Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits. Cell Metabolism, 2019, 31 (4), pp.755-772.e7. ⟨10.2139/ssrn.3382436⟩. ⟨hal-03347311⟩
23 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More