Serpentinization of mantle peridotites has first order effects on the rheology and tectonic behavior of the oceanic lithosphere, on the global water cycle, and on the biosphere at mid-oceanic ridges. Investigating serpentinization of abyssal peridotites is limited by the scarce occurrences of peridotites at or close to the ocean floor at slow and ultra-slow ridge environments where peridotite is exposed by long-lived detachments. The processes controlling hydration of the upper mantle below a thick magmatic crust at fast spreading ridges are poorly constrained. Here we present results based on samples from cores drilled in peridotites from the Samail ophiolite obtained during the Oman Drilling Project. We describe an early generation of highly localized brittle faults ubiquitous through all the peridotite cores and investigate their relation to the main serpentinization event represented by mesh-textured serpentinites. We combine microstructural observations with mineral and bulk chemical analyses as well as oxygen isotope microanalyses obtained by secondary ion mass spectrometry (SIMS). Asymmetric wall rock damage, weakening of crystal preferred orientation (CPO) in small fault clasts, and intense fragmentation within the fault zones even in association with very small displacements suggest that the early stage faults represent seismic events and predate mesh formation. Hydration and mesh texture formation follows in the wake of this faulting. Serpentinization is associated with moderate enrichment of fluid mobile elements including B, Li, Rb and U, indicative of fluid rock interaction characterized by relatively low fluid/rock ratios. This is consistent with a scenario where serpentinization took place below a thick magmatic crust following an earthquake-induced permeability increase. The oxygen isotope compositions of mesh serpentine are consistent with off-axis serpentinization at temperatures in the range 200-250 °C