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Article Dans Une Revue Analytical and Bioanalytical Chemistry Année : 2021

Development and validation of a UPLC-MS/MS method for the quantification of isothiazolinones in the composition and emissions from consumer products

Résumé

Isothiazolinones, a family of biocides, are used as preservatives for their fungicidal, bactericidal, and algacidal properties. These compounds can be found in a wide range of consumer and building products, such as paints, varnishes, shampoos, and liquid detergents. A robust analytical UPLC-MS/MS method to identify and quantify seven isothiazolinones (MIT, CMI, BIT, MBIT, BBIT, OIT, and DCOIT) in consumer products and their emissions was developed and validated according to ISO/IEC 17025. The limits of detection (LODs) ranged from 0.14 µg L-1 (BIT) to 0.54 µg L-1 (CMI). The method was applied for the quantification of the seven isothiazolinones in four types of consumer products (i.e., cosmetics, air fresheners, cleaning products, and building products) and the indoor emissions from a paint. Matrix effects were observed for the shampoo (63-74%), the shower gel (67-84%), and the ceramic glass cleaner (53-57%). All isothiazolinones indicated by the manufacturer (i.e., MIT, CMI, BIT, OIT, and DCOIT) were detected in the products and successfully quantified by the UPLC-MS/MS method.
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Dates et versions

hal-03339291 , version 1 (09-09-2021)

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Léa Ducup de Saint Paul, Sylvain Ravier, Henri Wortham, François Maupetit, Mélanie Nicolas, et al.. Development and validation of a UPLC-MS/MS method for the quantification of isothiazolinones in the composition and emissions from consumer products. Analytical and Bioanalytical Chemistry, In press, 413 (26), pp.6617-6626. ⟨10.1007/s00216-021-03627-7⟩. ⟨hal-03339291⟩
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