Concomitant Peripheral Neuropathy and Type 2 Diabetes Impairs Postexercise Cutaneous Perfusion and Flowmotion - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Clinical Endocrinology and Metabolism Année : 2021

Concomitant Peripheral Neuropathy and Type 2 Diabetes Impairs Postexercise Cutaneous Perfusion and Flowmotion

Cécile Reynès
  • Fonction : Auteur
Jean-Baptiste Beaume
  • Fonction : Auteur
Françoise Latil-Plat
  • Fonction : Auteur
Houda Ennaifer
  • Fonction : Auteur
Laure Rocher
  • Fonction : Auteur
Eric Benamo
  • Fonction : Auteur
Yannick Knapp
  • Fonction : Auteur
Agnès Vinet

Résumé

Abstract Context Type 2 diabetes and peripheral neuropathy exhibit microvascular dysfunction at rest. However, data regarding their microvascular perfusion during exercise remain scarce. Objective This study investigated changes in microvascular perfusion during postexercise recovery in those with type 2 diabetes, with or without peripheral neuropathy, as well as in healthy controls and those with obesity. Methods Skin blood perfusion was assessed in each group using laser Doppler flowmetry (LDF) and laser speckle contrast imaging before and immediately after a 6-minute walking test. LDF recordings underwent wavelet transformation to allow specific control mechanisms of blood perfusion to be studied (eg, endothelial nitric oxide–independent and –dependent, neurogenic, myogenic, respiratory, and cardiac mechanisms). Results Skin blood perfusion increased after exercise in all groups (22.3 ± 28.1% with laser speckle contrast imaging and 22.1 ± 52.5% with LDF). Throughout postexercise recovery, the decrease was blunted in those with subclinical peripheral neuropathy and confirmed peripheral neuropathy when compared to the other 3 groups. After exercise, total spectral power increased in all groups. The relative contributions of each endothelial band was lower in those with confirmed peripheral neuropathy than in the healthy controls and those with obesity (nitric oxide–dependent function: 23.6 ± 8.9% vs 35.5 ± 5.8% and 29.3 ± 8.8%, respectively; nitric oxide–independent function: 49.1 ± 23.7% vs 53.3 ± 10.4% and 64.6 ± 11.4%, respectively). The neurogenic contribution decreased less in those with confirmed peripheral neuropathy and in those with type 2 diabetes alone, compared to those with subclinical peripheral neuropathy and those with obesity (–14.5 ± 9.9% and –12.2 ± 6.1% vs –26.5 ± 4.7% and –21.7 ± 9.4%, respectively). Conclusion Peripheral neuropathy, whatever the stage, altered the microvascular response to exercise via impaired endothelial and neurogenic mechanisms.
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Dates et versions

hal-03338396 , version 1 (08-09-2021)

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Cécile Reynès, Jean-Baptiste Beaume, Françoise Latil-Plat, Houda Ennaifer, Laure Rocher, et al.. Concomitant Peripheral Neuropathy and Type 2 Diabetes Impairs Postexercise Cutaneous Perfusion and Flowmotion. Journal of Clinical Endocrinology and Metabolism, 2021, ⟨10.1210/clinem/dgab414⟩. ⟨hal-03338396⟩

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