Bronchodilator response and lung function decline: Associations with exhaled nitric oxide with regard to sex and smoking status - Archive ouverte HAL
Article Dans Une Revue World Allergy Organization Journal Année : 2021

Bronchodilator response and lung function decline: Associations with exhaled nitric oxide with regard to sex and smoking status

1 Uppsala University
2 Dalarna University
3 School of Public Health and Preventive Medicine [Melbourne, Australia]
4 UFPR - Universidade Federal do Parana [Curitiba]
5 UA - University of Antwerp
6 Aarhus University [Aarhus]
7 Tartu University Hospital [Tartu, Estonia]
8 BPH - Bordeaux population health
9 Landspitali National University Hospital of Iceland
10 University of Iceland [Reykjavik]
11 CHU Montpellier
12 Hôpital Arnaud de Villeneuve [CHU Montpellier]
13 EPAR - Epidemiology of Allergic and Respiratory Diseases Department [iPlesp]
14 IDESP - Institut Desbrest de santé publique
15 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
16 German Research Center for Environmental Health - Helmholtz Center München (GmbH)
17 University of Melbourne
18 German Center for Lung Research
19 Foundation IRCCS Policlinico San Matteo
20 UNIPV - Università degli Studi di Pavia = University of Pavia
21 UNIVR - Università degli studi di Verona = University of Verona
22 UNITO - Università degli studi di Torino = University of Turin
23 Haukeland University Hospital
24 UiB - University of Bergen
25 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
26 Galdakao Hospital
27 Hospital Universitario Juan Ramón Jiménez [Huelva]
28 GU - Göteborgs Universitet = University of Gothenburg
29 Umeå University = Umeå Universitet
30 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
31 Imperial College London
Isabel Urrutia
  • Fonction : Auteur
Jose Antonio Gullon
  • Fonction : Auteur
Christer Janson

Résumé

BACKGROUND: Fractional exhaled nitric oxide (FeNO) is a marker of type-2 inflammation used both to support diagnosis of asthma and follow up asthma patients. The associations of FeNO with lung function decline and bronchodilator (BD) response have been studied only scarcely in large populations. OBJECTIVES: To study the association between FeNO and a) retrospective lung function decline over 20 years, and b) lung function response to BD among asthmatic subjects compared with non-asthmatic subjects and with regards to current smoking and sex. METHODS: Longitudinal analyses of previous lung function decline and FeNO level at follow-up and cross-sectional analyses of BD response and FeNO levels in 4257 participants (651 asthmatics) from the European Community Respiratory Health Survey. RESULTS: Among asthmatic subjects, higher percentage declines of FEV(1) and FEV(1)/FVC were associated with higher FeNO levels (p = 0.001 for both) at follow-up. These correlations were found mainly among non-smoking individuals (p = 0.001) and females (p = 0.001) in stratified analyses.Percentage increase in FEV(1) after BD was positively associated with FeNO levels in non-asthmatic subjects. Further, after stratified for sex and smoking separately, a positive association was seen between FEV(1) and FeNO levels in non-smokers and women, regardless of asthma status. CONCLUSIONS: We found a relationship between elevated FeNO and larger FEV(1) decline over 20 years among subjects with asthma who were non-smokers or women. The association between elevated FeNO levels and larger BD response was found in both non-asthmatic and asthmatic subjects, mainly in women and non-smoking subjects.
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hal-03337837 , version 1 (08-09-2021)

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Elisabet Nerpin, Diogenes Seraphim Ferreira, Joost Weyler, Vivi Schlunnsen, Rain Jogi, et al.. Bronchodilator response and lung function decline: Associations with exhaled nitric oxide with regard to sex and smoking status. World Allergy Organization Journal, 2021, 14 (5), pp.100544. ⟨10.1016/j.waojou.2021.100544⟩. ⟨hal-03337837⟩
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