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Article Dans Une Revue Movement Disorders Année : 2021

Increased Risk of Parkinson's Disease in Women after Bilateral Oophorectomy

Résumé

Background: Results regarding the association between hormonal exposure and risk of Parkinson's disease (PD) are heterogeneous. Objectives: To investigate the association of reproductive life characteristics with PD among postmenopausal women. Methods: The PARTAGE case–control included 130 female cases and 255 age-matched female controls. Information on gynecological history was obtained from a standardized questionnaire and PD was validated by neurological examination. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed using conditional logistic regression. Results: After adjustment for education level, smoking status, professional exposure to pesticides, and coffee and alcohol drinking, bilateral oophorectomy (OR = 3.55, 95%CI = 1.75–7.20), but neither menopause before age 50 years (OR = 1.24, 95%CI = 0.74–2.09) nor hormone therapy (HT; OR = 1.07, 95%CI = 0.62–1.86), was associated with PD. Conclusion: Our findings suggest that bilateral oophorectomy is associated with increased risk of PD.
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Dates et versions

hal-03329899 , version 1 (25-10-2021)

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Marianne Canonico, Giancarlo Pesce, Audrey Bonaventure, Maryline Le Noan-Lainé, Isabelle Benatru, et al.. Increased Risk of Parkinson's Disease in Women after Bilateral Oophorectomy. Movement Disorders, 2021, 36 (7), pp.1696-1700. ⟨10.1002/mds.28563⟩. ⟨hal-03329899⟩
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