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Article Dans Une Revue Marine drugs Année : 2021

Marine Transcriptomics Analysis for the Identification of New Antimicrobial Peptides

Résumé

Antimicrobial peptides (AMPs) participate in the immune system to avoid infection, are present in all living organisms and can be used as drugs. Fish express numerous AMP families including defensins, cathelicidins, liver-expressed antimicrobial peptides (LEAPs), histone-derived peptides, and piscidins (a fish-specific AMP family). The present study demonstrates for the first time the occurrence of several AMPs in lionfish (Pterois volitans). Using the lionfish transcriptome, we identified four transcript sequences encoding cysteine-rich AMPs and two new transcripts encoding piscidin-like peptides. These AMPs are described for the first time in a species of the Scorpaenidae family. A functional approach on new pteroicidins was carried out to determine antimicrobial sequences and potential uses, with a view to using some of these AMPs for human health or in aquaculture.
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Dates et versions

hal-03329592 , version 1 (31-08-2021)

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Baptiste Houyvet, Yolande Bouchon-Navaro, Claude Bouchon, Erwan Corre, Céline Zatylny-Gaudin. Marine Transcriptomics Analysis for the Identification of New Antimicrobial Peptides. Marine drugs, 2021, 19 (9), pp.490. ⟨10.3390/md19090490⟩. ⟨hal-03329592⟩
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